Skip to main content
. 2011 May 31;52(6):3825–3831. doi: 10.1167/iovs.10-6797

Figure 2.

Figure 2.

Effect of edaravone on ONL thickness ratio and photoreceptor cell death with TUNEL staining compared with saline treatment 3 and 5 days after RD. Quantification of TUNEL (+) cells showed significantly decreased TUNEL (+) cells/mm2 with treatment of (B) 5 and (C) 10 mg/kg edaravone, compared with the saline-treated group (A) at 3 days after RD creation (both, P < 0.01). (D) Five days after RD creation, 10 mg/kg edaravone treatment showed a significant increase in photoreceptor cell death (P = 0.004). (E) Treatment with 5 mg/kg edaravone significantly prevented the reduction of the ONL thickness ratio on days 3 and 5 after RD (P < 0.001 and P = 0.041, respectively). Whereas treatment with 10 mg/kg showed a protective effect on day 3 (P = 0.041), prolonged treatment until day 5 showed no added protective effect (P = 0.25). Data are expressed as the mean ± SE n = 5–7. *P < 0.05. **P < 0.01. GCL, ganglion cell layer; Eda, Edaravone. Original magnification: (A–C) ×10; scale bar, 100 μm.