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. 2011 May 31;52(6):3825–3831. doi: 10.1167/iovs.10-6797

Figure 6.

Figure 6.

Effect of edaravone on levels of Bcl-2, Bax, p-ERK1/2, and total ERK1/2 in AR, RD, and RD treated with 5 mg/kg edaravone (A). Retinas were harvested at 24 hours after RD. Whereas there was no change in the level of Bcl-2 after RD compared to AR, an increased level of Bcl-2 was noted after treatment with edaravone (C). An increased level of Bax was noted after RD, and it did not change with edaravone treatment (D). There was a marked increase in the level of phosph-ERK1/2 after RD. However, a decrease was noted after edaravone treatment (B). There was no change in the total ERK1/2 levels. *P < 0.05, **P < 0.01. Data are expressed as the mean ± SE n = 4–6.