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Nuclei were significantly larger in WT mice than in CP49 KO mice in both the middle-aged and old age groups (P < 0.01; nuclei were not visible in young mice). Regressions of nuclear diameter versus lens volume demonstrated that the differences in nuclear size between WT and CP49 KO mice are not simply a result of larger lens size in the WTs; nuclei are larger in WTs for a given lens volume as well (P < 0.001).
