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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Epilepsy Res. 2011 Mar 22;95(1-2):9–19. doi: 10.1016/j.eplepsyres.2011.01.019

Figure 4. Combination of prenatal exposure to hydrocortisone and postnatal seizures decreases transfer latency in the elevated-plus maze.

Figure 4

(A) There was no effect of either prenatal hydrocortisone or prenatal betamethasone exposure on horizontal bar performance on P15 (prior to seizure challenge) or on P17 (tested after the P15 seizure experience).

(B) Only prenatal exposure to hydrocortisone in combination with P15 seizures significantly decreased transfer latency in the elevated plus maze assessed on P20 (*p<0.05 versus controls; #p<0.05 versus prenatal betamethasone-exposure) indicating increased anxiety.

(C) Both prenatal hydrocortisone and betamethasone exposure in combination with P15 seizures did not alter retention index determined on P20-22 in the elevated plus maze compared to saline-exposed controls.