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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Epilepsy Res. 2011 Mar 22;95(1-2):9–19. doi: 10.1016/j.eplepsyres.2011.01.019

Figure 5. Prenatal hydrocortisone exposure without seizure experience improves horizontal bar holding in the repeated test.

Figure 5

(A) Bar holding determined on P15 was not affected by prenatal hydrocortisone exposure compared to controls.

(B) When the horizontal bar holding was repeated on P17, those rats exposed prenatally to hydrocortisone significantly improved performance compared to controls (*p<0.05).

(C) There was no effect of prenatal hydrocortisone exposure on transfer latency determined in the elevated plus maze on P20.

(D) Prenatal hydrocortisone exposure did not affect memory retention index calculated from the transfer latency on P20 and P22 in the elevated plus maze.

(E) Prenatal co-administration of canrenoic acid (CAN) and hydrocortisone (HC) significantly decreased performance on the horizontal bar compared to both prenatally saline-exposed controls (*p<0.05) and to controls injected with canrenoic acid and saline (#p<0.05).