Table 1.
prenatal exposure G15 | seizure induction on P15 | ||
---|---|---|---|
flurothyl | kainic acid 3.5 mg/kg | kainic acid 5.0 mg/kg | |
saline | 25/25 | 29/30 | 17/33 |
betamethasone 2× 0.4 mg/kg | 7/7 | 21/24 | 5/8 |
hydrocortisone 2× 10 mg/kg | 23/23 | 7/14 | 13/25 |
| |||
statistics: χ2, p | n/a | 15.7; 0.0004* | 0.329; 0.8483 |
First number in the field marks the number of rats surviving on P17 while the second number indicates the number of rats tested in the particular seizure test on P15. All rats experiencing fluorthyl seizures survived. On the other hand, prenatal hydrocortisone treatment significantly decreased survival rate after seizures induced by 3.5 mg/kg of kainic acid i.p.