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. Author manuscript; available in PMC: 2012 Jun 27.
Published in final edited form as: Neurosci Lett. 2011 Mar 4;497(3):205–212. doi: 10.1016/j.neulet.2011.02.041

Figure 2. A systems biology model for high-throughput studies of epilepsy.

Figure 2

Within a cell, such as the neuron shown here, genetic differences as well as differences in gene expression (mRNA), protein expression, and small molecule expression (such as neurotransmitters) characterize the epileptic focus. These individual molecular systems must also be placed within the contexts of larger systems including organ, tissue, and cell type. The complexity of this system creates one of the greatest challenges for the study and interpretation of high-throughput molecular profiling methods in epilepsy.