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. Author manuscript; available in PMC: 2012 Jun 27.
Published in final edited form as: Neurosci Lett. 2011 Mar 4;497(3):205–212. doi: 10.1016/j.neulet.2011.02.041

Figure 4. Model of epileptogenesis from genes to pathways identified from functional genomics studies.

Figure 4

Based on the pattern of gene activations in human neocortical regions of seizure onset, this model describes how ongoing epileptic activities could create a state of heightened signaling through a number of pathways including the CREB transcription factor [59]. Some of these pathways that are known to activate CREB signaling such as protein kinase A (PKA), calcium calmodulin kinase II (CAMKII), or mitogen activated protein kinase (MAPK) could be targeted for anti-epileptic drug development.