Table 3.
Predicting Orthology Using Synteny Relationship
| Zebrafish gene | Reference NCBI gi | Zebrafish map position | Human synteny predictionsa | Possible human orthologues | Reference NCBI unigene | Human map position |
|---|---|---|---|---|---|---|
| bact | 3044209 | 1.59cRb | 1, 2 | ACTB | Hs.180952 | 1.49-82cM |
| ACTG1 | Hs.204867 | 17.118-129cM | ||||
| ACTC | Hs.118127 | 15.25-32cM | ||||
| bact2 | 2822455 | 3.304cRg | 16, 17 | ACTG1 | Hs.204867 | 17.118-129cM |
| ACTB | Hs.180952 | 1.49-82cM | ||||
| ACTC | Hs.118127 | 15.25-32cM | ||||
| brn1.2 | 222975 | 6.218cRd | 1, 2, 9, 17 | POU3F1 | Hs.1837 | 1.49-82cM |
| POU3F2 | Hs.182505 | 6.91-96cM | ||||
| POU3F3 | Hs.248158 | 3.80-100 | ||||
| POU3F4 | Hs.2229 | X.97-105cM | ||||
| elrd | 608548 | 8.108cRd | 1 | ELAVL4 | Hs.75236 | 1.49-82cM |
| ELAVL2 | Hs.3198 | 9.57-93cM | ||||
| frz-zg01 | 1245183 | 15.272cRg | 2, 3, 11, 17 | FZD4 | II.8322 | 11.84-100cM |
| FZD9 | Hs.158335 | 7.84-91cM | ||||
| glr | 3378595 | 14.433cRb | 5, 11, 12 | GLRA1 | Hs.121490 | 5.153-158cM |
| GLRA3 | Hs.167742 | 4.170cM | ||||
| GLRA2 | Hs.2700 | X.0-42cM | ||||
| groucho1 | 2104717 | 7.119cRb | 11, 15, 16 | TLE3 | Hs.167086 | 15.70-71cM |
| TLE1 | Hs.28935 | 9 | ||||
| TLE4 | Hs.83958 | 9.77.7-82.3cM | ||||
| TLE2 | Hs.173063 | 19.0.0-31.9cM | ||||
| hha | N/A | 9.140cRe | 2 | IHH | Hs.69351 | 2.200-215cM |
| SHH | Hs.121539 | 7.181-184cM | ||||
| Idb4 | 3078004 | 13.278cRg | 2, 6, 10 | LDB1 | Hs.26002 | 10.114-131cM |
| LDB2 | Hs.4980 | 4.0-32cM | ||||
| msxa | 608508 | 14.464cRe | 5 | MSX2 | Hs.89404 | 5.185-199cM |
| MSX1 | Hs.194 | 4.4-28cM | ||||
| MSX3 | Mm.4816 | 10.170-182cMc | ||||
| msxb | 608510 | 1.381cRb | 4, 13, 14 | MSX1 | Hs.194 | 4.4-28cM |
| MSX2 | Hs.89404 | 5.185-196cM | ||||
| MSX3 | Mm.4816 | 10.170-182cMc | ||||
| msxc | 399912 | 13.312cRd | 6, 10 | MSX3 | Mm.4816 | 10.170-182cMc |
| MSX1 | Hs.194 | 4.4-28cM | ||||
| MSX2 | Hs.89404 | 5.185-196cM | ||||
| msxd | 62544 | 21.211cRd | 5, 7, 10 | MSX2 | Hs.89404 | 5.185-196cM |
| MSX2 | Hs.89404 | 5.185-196cM | ||||
| MSX3 | Mm.4816 | 10.170-182cMc | ||||
| msxe | 1399516 | 14.27cRd | 5, 6, 8, 22 | MSX2 | Hs.89404 | 5.185-196cM |
| MSX1 | Hs.194 | 4.4-28cM | ||||
| MSX3 | Mm.4816 | 10.170-182cMc | ||||
| otx3 | 633134 | 1.381cRd | 4, 7, 14 | OTX2 | II.5015 | 14.0-1cM |
| OTX1 | II.5013 | 2.84-88cM | ||||
| plasticin | 1881763 | 11.390cRf | 3, 12, 17 | PRPH | Hs.37044 | 12.53-70cM |
| VIM | Hs.2064 | 10.40-44cM | ||||
| rtk7 | 3005904 | 24.301cRb | 4, 8 | EPHA5 | Hs.31092 | 4.67.7-77.9cM |
| EHK-1 | Hs.194771 | N/A | ||||
| EPHNA4 | Hs.739641 | N/A | ||||
| EPHA7 | Hs.73962 | 6.101-104cM | ||||
| EPHA3 | Hs.123642 | 3.111-113cM | ||||
| zef1 | 4099173 | 14.534cRd | 4, 5, 12, X | ELF4 | Hs.151139 | X.150-184cM |
| ELF1 | Hs.154365 | 13.37-46cM | ||||
| fb38g02 | 6.115cRb | 2, 19 | FZD7 | Hs.173859 | 2.200-212cM | |
| FZD2 | Hs.81217 | 17.74-75cM | ||||
| fb18b11 | 24.388cRb | 1, 8 | UBE2V2 | Hs.79300 | 8.66-67cM | |
| UBE2V1 | Hs.75875 | 20.74-75cM | ||||
| FZD10 | Hs.31664 | 12.160-169cM |
Human genes in bold are orthologues predicted by sytenic correspondence.
a
Corresponding human synteny group or groups for zebrafish genes in same mapping bin or flanking positions to zebrafish gene in column 1.
b
Genes and ESTs mapped in this study.
c
Corresponding human map position inferred from human-mouse syntenic relationship and mouse gene position.