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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Gastroenterology. 2011 Feb 24;140(7):2095–2106. doi: 10.1053/j.gastro.2011.02.055

Figure 1. Loss of PXR sensitized mice to CGD.

Figure 1

Male WT and PXR-/- mice were subjected to lithogenic diet for 4 weeks. (A) Incidence of gallstones with the numbers of mice labeled. (B) Gross appearance of representative gallbladders. (C) Polarizing light microscopic examination of cholesterol crystals. (D) Histological examination of the gallbladder by H&E staining. The arrow indicates the thickness of the gallbladder wall and stromal granulocyte infiltration. The arrowhead indicates submucosal vasodilatation.