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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Gastroenterology. 2011 Feb 24;140(7):2095–2106. doi: 10.1053/j.gastro.2011.02.055

Figure 4. Effect of loss of PXR on the expression of cholesterol and phospholipid transporters and genes involved in bile acid synthesis. (A and B).

Figure 4

Hepatic expression of phospholipid transporters (A), and hepatic and ileum expression of cholesterol transporters (B) as measured by real-time PCR. (C) Hepatic expression bile acid synthesis enzyme genes. (D) Expression of Cyp7a1 protein was measured by Western blot analysis. (E) SHP and Fgf15 mRNA expression in the ileum (top panel), and Fgf15 protein expression in the serum and ileum (bottom panel). (F) Hepatic mRNA expression of Fgfr4 and β-Klotho. N=5 for each group. * P<0.05; **P<0.01.