A. When Y23, a phosphorylation target of src kinases, is mutated (Y23A), A2 fails to translocate to the cell surface in response to thermal stress. B. Following knockdown of p11 by RNA silencing, A2 fails to translocate to the cell surface in response to thermal stress. C. Following inhibition of tyrosine kinase activity with herbimycin A, A2 fails to translocate to the cell surface. Reprinted with permission from (Deora et al., 2004).