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. Author manuscript; available in PMC: 2012 Mar 29.
Published in final edited form as: Vascul Pharmacol. 2011 Mar 29;54(3-6):59–67. doi: 10.1016/j.vph.2011.03.003

Figure 4. Fibrin accumulation and impaired angiogenesis in Anxa−/− mice.

Figure 4

A. Immunoblot analysis of extracts of five tissues from AnxaA2+/+ or AnxaA2−/− mice (n=4) shows increased fibrin deposition in AnxaA2−/− tissues. Standards (lanes 1–3) represent 2, 5 and 10 ng for lung, spleen, and small intestine, and 1, 2, and 5 ng for liver and kidney. B. Hematoxylin and eosin-stained sections of retinas from AnxaA2+/+ and AnxaA2−/− mice studied in the oxygen-induced retinopathy model of angiogenesis. Neonatal mouse pups were maintained in either room air (RA) or a 75% oxygen atmosphere (O2) from day 7 through day 12 of life. Neoangiogenesis is prominent in AnxaA2+/+ retinas exposed to high oxygen (green arrows), but not in equally treated AnxaA2−/− mice. Green arrowheads indicate dilated intraretinal blood vessels. Reprinted with permission from (Ling et al., 2004).