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. Author manuscript; available in PMC: 2012 Mar 29.
Published in final edited form as: Vascul Pharmacol. 2011 Mar 29;54(3-6):59–67. doi: 10.1016/j.vph.2011.03.003

Figure 5. Homocysteine disables A2 in vivo.

Figure 5

A. Hyperhomocysteinemia, produced by a high methionine diet, promotes fibrin accumulation and impaired perivascular fibrinolysis in mice. Representative sections of extensively perfused renal tissue from mice on normal chow, glycine-enriched (Gly), or methionine-enriched (Met) diets were stained with rabbit anti-human fibrin(ogen) IgG, followed by CY3-conjugated rabbit IgG (red) and DAPI (blue). Tissue autofluorescence is green. Original magnification, ×400. Scale bars: 100 μm. B. Corneal angiogenesis in response to implantation of bFGF-containing pellets was decreased in mice maintained on a high methionine diet as compared to those on chow or high glycine diets. However, neovascular growth was restored in methionine fed mice upon receiving 5 daily tail vein injections of rA2, but not similar injections of BSA. Shown are representative photographs of corneal neovessels. Reprinted with permission from (Jacovina et al., 2009).