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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Gastroenterology. 2011 Mar 9;140(7):1934–1942. doi: 10.1053/j.gastro.2011.02.063

Figure 1.

Figure 1

Molecular mechanisms in homeostatic control of bile acid synthesis. FGF19 plays an important role in BA homeostasis by binding to FGFR4 on the hepatocyte cell membrane, triggering intracellular signaling in a KLB-dependent manner to downregulate CYP7A1 expression and thereby suppress BA synthesis. Defective FGF19 release from the ileum is reported in IBS-D patients whose symptoms improve with the BA sequestrant cholestyramine, suggesting that excessive hepatic BA synthesis due to defective FGF19 signaling is associated with BA diarrhea (adapted from Rao et al.)24.