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. Author manuscript; available in PMC: 2012 Jun 1.

Published in final edited form as: Gastroenterology. 2011 Mar 9;140(7):1934–1942. doi: 10.1053/j.gastro.2011.02.063

KLB rs17618244’s association with colonic transit in IBS-D is modulated separately by two FGFR4 variants. Colonic transit expressed as mean GC24 (y-axis) is shown by combinations of 2 genotype groups: KLB rs17618244 with either FGFR4 rs351855 (panel A) or FGFR4 rs1966265 (panel B). IBS-D patients generally have accelerated colonic transit. The GG genotype of KLB SNP rs17618244 is associated with accelerated colonic transit, but this association is significantly modulated separately by the genotypes of FGFR4 SNPs rs351855 and rs1966265, with rs351855 GG and rs1966265 AA/GA blunting this acceleration whereas rs351855 AA/GA and rs1966265 GG enhancing this acceleration.

KLB rs17618244’s association with colonic transit in IBS-D is modulated separately by two FGFR4 variants. Colonic transit expressed as mean GC24 (y-axis) is shown by combinations of 2 genotype groups: KLB rs17618244 with either FGFR4 rs351855 (panel A) or FGFR4 rs1966265 (panel B). IBS-D patients generally have accelerated colonic transit. The GG genotype of KLB SNP rs17618244 is associated with accelerated colonic transit, but this association is significantly modulated separately by the genotypes of FGFR4 SNPs rs351855 and rs1966265, with rs351855 GG and rs1966265 AA/GA blunting this acceleration whereas rs351855 AA/GA and rs1966265 GG enhancing this acceleration.