A: CDDO-EA treatment extends survival in G93A SOD1 mice. G93A SOD1 mice (n=18) were treated with CDDO-EA (starting at 30 days of age). The control group (n=18) was treated with control food (Chaw diet # 5002). The data were analyzed and compared using the Kaplan-Meier plot. Survival is significantly longer in CDDO-EA treated G93A SOD1 mice vs controls (p=0.001, Logrank, Mental-Cox).
B: CDDO-TFEA treatment extends survival in G93A SOD1 mice. G93A SOD1 mice (n=18) were treated with CDDO-TFEA (starting at 30 days of age). The control group (n=18) was treated with control food (Chaw diet # 5002). The data were analyzed and compared using the Kaplan-Meier plot. Survival is significantly longer in CDDO-TFEA-treated G93A SOD1 mice vs controls (P=0.001, Logrank, Mental-Cox).