Table 2.
Multivariate Cox proportional hazards models of overall survival and melanoma-specific survival
| Hazard ratio | 95% confidence interval | P value | |
|---|---|---|---|
| Overall survival | |||
| Age | 1.03 | 1.02–1.03 | <0.001* |
| Sex | |||
| Male (referent) | (referent) | (referent) | (referent) |
| Female | 0.79 | 0.73–0.86 | <0.001* |
| Breslow depth, mm | |||
| 0 mm (referent) | (referent) | (referent) | (referent) |
| ≤1 mm | 0.84 | 0.73–0.96 | =0.01* |
| 1.01–2 mm | 1.10 | 0.97–1.25 | =0.148 |
| 2.01–4 mm | 1.52 | 1.33–1.72 | <0.001* |
| >4 mm | 0.88 | 0.63–1.24 | =0.457 |
| Unknown | 1.19 | 1.03–1.37 | =0.017* |
| Ulceration | |||
| Absent (referent) | (referent) | (referent) | (referent) |
| Present | 1.29 | 1.18–1.41 | <0.001* |
| Number of lymph Node metastases | |||
| 1 (referent) | (referent) | (referent) | (referent) |
| 2–3 | 1.46 | 1.33–1.59 | <0.001* |
| ≥4 | 2.54 | 2.28–2.83 | <0.001* |
| Unknown | 2.10 | 1.79–2.47 | <0.001* |
| Type of surgery | |||
| Local excision (referent) | (referent) | (referent) | (referent) |
| Amputation | 2.58 | 0.64–10.39 | =0.182 |
| Ablation | 1.11 | 0.81–1.52 | =0.531 |
| Wide excision (1–2 cm) | 1.07 | 0.83–1.38 | =0.60 |
| Wide excision (>2 cm) | 1.09 | 0.92–1.30 | =0.317 |
| None | 0.90 | 0.79–1.02 | =0.094 |
| Unknown | 0.78 | 0.59–1.04 | =0.096 |
| Era | |||
| Era I (referent) | (referent) | (referent) | (referent) |
| Era II | 0.89 | 0.78–1.01 | =0.065 |
| Melanoma-specific survival | |||
| Age | 1.02 | 1.02–1.02 | <0.001* |
| Sex | |||
| Male (referent) | (referent) | (referent) | (referent) |
| Female | 0.80 | 0.73–0.88 | <0.001* |
| Breslow depth, mm | |||
| 0 mm (referent) | (referent) | (referent) | (referent) |
| ≤1 mm | 0.83 | 0.71–0.97 | =0.023* |
| 1.01–2 mm | 1.16 | 1.01–1.34 | =0.038* |
| 2.01–4 mm | 1.61 | 1.39–1.87 | <0.001* |
| >4 mm | 0.91 | 0.62–1.33 | =0.646 |
| Unknown | 1.29 | 1.10–1.51 | =0.002* |
| Ulceration | |||
| Absent (referent) | (referent) | (referent) | (referent) |
| Present | 1.32 | 1.19–1.47 | <0.001* |
| Number of lymph node metastases | |||
| 1 (referent) | (referent) | (referent) | (referent) |
| 2–3 | 1.51 | 1.36–1.67 | <0.001* |
| ≥4 | 2.71 | 2.41–3.06 | <0.001* |
| Unknown | 2.20 | 1.84–2.64 | <0.001* |
| Type of surgery | |||
| Local excision (referent) | (referent) | (referent) | (referent) |
| Amputation | NA | NA | NA |
| Ablation | 1.18 | 0.84–1.68 | =0.34 |
| Wide excision (1–2 cm) | 1.06 | 0.80–1.41 | =0.67 |
| Wide excision (>2 cm) | 1.04 | 0.86–1.26 | =0.713 |
| None | 0.86 | 0.75–0.99 | =0.035* |
| Unknown | 0.68 | 0.49–0.96 | =0.028* |
| Era | |||
| Era I (referent) | (referent) | (referent) | (referent) |
| Era II | 0.81 | 0.70–0.93 | =0.003* |
* Indicates statistical significance (P ≤ 0.05)