Table 2.
Specifications of the included articles
| Year of publication | First author | Number of Hurler patients | Age at HSCT (months) | Follow up since HSCT (months) | Major topics |
|---|---|---|---|---|---|
| 1986 | Hugh-Jones | 5 | 19.6 | 37.8 | Kyphosis, gait, hand dexterity, joint ROM, growth |
| 1993 | Belani | 30 | C1-2 instability, odontoid dysplasia, cord compression, neurological symptoms | ||
| 1993 | Hopwood | 3 | 13 | > 120 | Kyphosis, hip dislocation, genu valgum, CTS, gait, joint ROM and surgical procedures * |
| 1994 | Bona | 1 | CTS (surgery) | ||
| 1994 | Field | 11 | 19.5 | 111 | Kyphosis, hip dysplasia, genu valgum, CTS, joint ROM, growth and surgical procedures |
| 1996 | Masterson | 8 | 9 | 28 | Hip dysplasia (surgery), gait |
| 1996 | Tandon | 12 | 16 | 54 | C1-2 instability, odontoid dysplasia, soft tissue deposition, cord compression, vertebral abnormalities, kyphosis (surgery), scoliosis, disc abnormalities, spondylolisthesis, neurological symptoms |
| 1997 | Vellodi | 10 | 17 | 134.4 | C1-2 instability, odontoid hypoplasia, soft tissue deposition, cord compression, kyphosis, hip dysplasia, gait, motor development, hand dexterity, growth and surgical procedures |
| 1998 | Flemming | 11 | 20 | 60 | Joint ROM |
| 1998 | Guffon | 9 | 60 | Kyphosis, hip dysplasia, genu valgum, CTS, joint ROM, growth and surgical procedures | |
| 1998 | van Heest | 15 | 21 | CTS and trigger finger surgery | |
| 1999 | Odunusi | 17 | 19 | Genu valgum (surgery) | |
| 2000 | Hite | 8 | 20 | 104.4 | Odontoid hypoplasia, soft tissue deposition, cord compression |
| 2000 | Kachur | 1 | 24 | 72 | Cord compression (surgery), soft tissue deposition, kyphosis, genu valgum, neurological symptoms, hand dexterity, muscle strength |
| 2001 | Dalvie | 1 | 48 | 12 | Kyphosis (surgery) |
| 2003 | Souillet | 11 | 24.2 | 90 | C1-2 instability, kyphosis, scoliosis, genu valgum, hip dysplasia, CTS, joint ROM, muscle strength, growth and surgical procedures |
| 2004 | Dumas | 1 | Gait, motor development | ||
| 2004 | Staba | 17 | 18 | 54 | Kyphosis, growth and surgical procedures |
| 2004 | Weisstein | 7 | 20 | 55.2 | C1-2 instability, soft tissue deposition, vertebral and disc abnormalities, kyphosis, hip dysplasia, genu valgum, CTS and trigger fingers, neurological symptoms, hand dexterity, joint ROM and surgical procedures |
| 2005 | Dusing | 2 | 22.5 | 10.5 | Motor development, hand dexterity, kyphosis, hip dislocation |
| 2005 | van Meir | 1 | CTS and kyphosis surgery | ||
| 2006 | Bjoraker | 41 | 21.7 | 67.2 | Motor development |
| 2006 | Ringdén | 4 | < 20 | Kyphosis (surgery), hip dislocation, gait, neurological symptoms | |
| 2007 | Dusing | 21 | 17.1 | 16.2 | Motor development, genu valgum |
| 2007 | Dusing | 18 | 18.8 | 29.9 | Gait |
| 2007 | Khanna | 43 | 19 | 103.2 | CTS (surgery) |
| 2007 | Lucke | 5 | 25 | 46 | Motor development, hand dexterity |
| 2008 | Malm | 6 | 18 | 67.2 | Hip dysplasia, CTS, neurological symptoms, hand dexterity, growth and surgical procedures |
| 2008 | Polgreen | 48 | 20 | 83 | Growth |
| 2008 | Taylor | 23 | 9.4 | 102 | Kyphosis, scoliosis, genu valgum, hip dysplasia, gait, joint ROM, muscle strength, growth and surgical procedures |
| 2009 | Polgreen | 8 | Kyphosis, genu valgum and surgical procedures | ||
| 2009 | Rebello | 1 | Hip dysplasia (surgery) |
HSCT = hematopoietic stem cell transplantation, ROM = range of motion, CTS = carpal tunnel syndrome
* Surgical procedures are not further specified in the current table