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Chemical structure of iron-chelating agents. Deferoxamine mesylate (DFO) is a hydrophilic compound with a high affinity for ferric iron (Martell and Smith, 1977). It binds ferric iron in a 1:1 (hexadentate) complex (Gaeta and Hider, 2005). 2,2′-bipyridyl (Bpdl) is a membrane permeable compound with similar moderate affinities for Fe2+ and Fe3+ (Smith and Martell, 1975), and binds both species of these molecules in a 3:1 molar ratio (bidentate; Gaeta and Hider, 2005).
