Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model for regulation of Francisella pathogenicity island gene expression. Unknown environmental signals are sensed by KdpD and relayed to the DNA binding protein PmrA. MglA and SspA heterodimerize and associate with RNA polymerase (RNAP). The regulatory activity of the MglA/SspA/RNAP complex is dependent on association of PmrA to the complex as well as the production of ppGpp, which promotes interaction of FevR/PigR with the MglA/SspA/RNAP complex.
