Table 1.

Transcription factors of Francisella tularensis identified by protein relatedness to known transcription factors/transcription factor motifs.

			Conservation in other Francisella					Experimentally studied in:
FTT# (Type A; Schu S4)	Gene	Description	W96-3418 (Type A)	FSC198 (Type A)	OSU18 (Type B)	LVS (Type B)	U112 (F. novicida)	Schu S4 (Type A)	LVS (Type B)	U112 (F. novicida)
30	fur	Fe transcriptional regulator	+	+	+	+	+	Ramakrishnan et al. (2008)	Deng et al. (2006)	Kiss et al. (2008)
94	qseC	Sensor histidine kinase	+	+	+	+	+	Rasko et al. (2008)		Weiss et al. (2007), Durham-Colleran et al. (2010)
112		Homolog of Bvg acc. factor	+	+	+	+	+
383	fevR/pigR	Transcriptional regulator	+	+	+	+	+	Wehrly et al. (2009)	Charity et al. (2007, 2009)	Brotcke and Monack (2008)
458	sspA	Stringent starvation protein A regulator	+	+	+	+	+		Charity et al. (2007, 2009)
492	lysR	Homolog of LysR	+	+	+	+	+
556	oxyR	Oxidative stress regulator	+	+	+	+	+			Moule et al. (2010)
748		Homolog of TtgV	+	+	+	+	+	Mortensen et al. (2010)	Mortensen et al. (2010)	Weiss et al. (2007), Mortensen et al. (2010)
864		LysR family regulator	+	+	−	−	+
932		ROK family regulator	−	+	−	+	+
970		Transcriptional repressor	+	+	+	+	+
977		MarR-like regulator	+	−	−	−	−
981		Sensor kinase	+	+	+	+	+
985		Transcriptional regulator	+	+	+	+	+
1010		Cro family regulator	−	−	−	−	−
1035	rpoD	Sigma factor	+	+	+	+	+		Grall et al. (2009)
1076	hipA	Homolog of HipA	−	+	+	+	−
1112	rpoH	Sigma factor	+	+	+	+	+		Grall et al. (2009)
1119		LysR family regulator	+	+	+	+	+
1172		Cold shock protein	+	+	−	+	−
1202		LysR family regulator	+	+	−	+	+
1255		AraC family regulator	+	+	+	+	+
1267		LysR family regulator	+	+	+	+	+
1275	mglA	Macrophage growth locus regulator	+	+	+	+	+		Bonquist et al. (2008), Charity et al. (2007, 2009)	Baron and Nano (1998), Brotcke et al. (2006), Guina et al. (2007)
1281	rpoN	Sigma factor	−	−	−	−	−
1285		LysR family regulator	+	+	−	+	+
1392		Homolog of Bvg acc. factor	+	+	+	+	+
1401		LexA homolog	+	+	+	+	+
1543		Response regulator	+	+	−	−	+
1557c	pmrA	Response regulator	+	+	+	+	+		Sammons-Jackson et al. (2008)	Bell et al. (2010), Mohapatra et al. (2007)
1594		LysR family regulator	+	+	+	+	−
1652		LysR family regulator	+	+	+	+	+
1613		Homolog of BolA	−	−	−	−	−
1684		Transcriptional regulator	+	+	−	+	+
1736	kdpD	Sensor kinase KdpD	+	+	−	+	+			Bell et al. (2010), Weiss et al. (2007