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. 2011 Feb 18;2:34. doi: 10.3389/fmicb.2011.00034

Table 2.

List of evolutionally conserved host factors involved in intracellular trafficking of F. tularensis in both D. melanogaster and human cells.

Category Description Drosophila Melanogaster gene Human homolog gene
Cell cycle Mitosis cdc27 CDC27*a
Proteolysis Ubiquitin thiolesterase activity not USP22a
Signal transduction Ras/Rho guanyl-nucleotide exchange factor activity sos SOS2b
Signal transduction 1-Phosphatidylinositol 4-kinase activity CG10260 PI4KCAa

*Indicates that this gene is also involved in escape of F. tularensis in HEK293T cells. aIndicates from a study by Akimana et al. (2010), and bindicates from a study by Al-Khodor and Abu Kwaik (2010).