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(A) Cell survival curve of House Ear Institute-Organ of Corti 1 (HEI-OC1) cells cultured with minocycline. Minocyline (mino) is cytotoxic at high, but not at low, concentrations. (B) Cell survival curve of HEI-OC1 cells cultured with cisplatin alone and with cisplatin (cis) after minocycline pretreatment. More cells survived in the 10 µM minocycline pretreatment condition compared with the cisplatin alone condition.
