Table 3.
Route of infection | Animal | Sex | Age or weight | Bacterial strain | LD50 or ID50 (CFU) | Duration of observation | Reference(s) |
---|---|---|---|---|---|---|---|
i.p. | Golden Syrian hamster | Female | 6–8 weeks | DD503 | 4, <10 | 2 days | Moore et al. (1999), Warawa and Woods (2005) |
i.p. | Golden Syrian hamster | Female | 6–8 weeks | E300 | <2 | 2 days | Brett et al. (1997) |
i.p. | Golden Syrian hamster | Female | 6–8 weeks | 316c | <10 | 2 days | Brett et al. (1997) |
i.p. | Golden Syrian hamster | Female | 6–8 weeks | 1026b | <10, <12, <2, <5 | 2 days | Brett et al. (1997), DeShazer et al. (1997, 1998), Jones et al. (1997), Moore et al. (1999), Reckseidler et al. (2001) |
i.p. | Golden Syrian hamster | Female | 6–8 weeks | 406e | <10 | 2 days | Moore et al. (2004) |
i.p. | Golden hamster | Female | 3–8 months | 103-67 | 16 | N.I. | Dannenberg and Scott (1958) |
Aerosol | Golden hamster | N.I. | 3–8 months | 103-67 | 16 | N.I. | Dannenberg and Scott (1958) |
i.p. | Golden hamster | N.I. | N.I. | C-141 | 9.5 | 45 days | Manzeniuk et al. (1999) |
s.c. | Golden hamster | N.I. | N.I. | C-141 | 3.6 | 45 days | Manzeniuk et al. (1999) |
i.p. | Hamster | N.I. | N.I. | W294 | 6 | 20–30 days | Miller et al. (1948) |
s.c. | Hamster | N.I. | N.I. | W294 | 10 | 20–30 days | Miller et al. (1948) |
Aerosol | Hamster | N.I. | N.I. | W294 | 70 | 20–30 days | Miller et al. (1948) |
i.p. | Landrace pig | Mix | 2 months | 2796 | >5.0 × 109 | 30 days | Najdenski et al. (2004) |
i.p. | Ferret | N.I. | N.I. | W294 | <76 | 15 days | Miller et al. (1948) |
i.p. | Hartley guinea pig | Female | 3–4 weeks | 1026b | 2 × 103 | 21 days | DeShazer et al. (1998) |
i.p. | Guinea pig | N.I. | N.I. | W294 | 440 | N.I. | Miller et al. (1948) |
i.p. | Guinea pig | N.I. | N.I. | C-141 | 5.5 | 45 days | Manzeniuk et al. (1999) |
s.c. | Guinea pig | N.I. | N.I. | C-141 | 4.6 | 45 days | Manzeniuk et al. (1999) |
i.p. | White rat | N.I. | N.I. | C-141 | 4.4 × 104 | 45 days | Manzeniuk et al. (1999) |
s.c. | White rat | N.I. | N.I. | C-141 | 1.1 × 106 | 45 days | Manzeniuk et al. (1999) |
i.p. | Sprague-Dawley infant diabetic rat | Male | 50 g | 1026b | 1.9 × 104, 2 × 104 | 7 days | DeShazer et al. (1997, 1998), Jones et al. (1997) |
i.p. | Sprague-Dawley infant diabetic rat | Male | 50 g | 316c | 9.53 × 103 avg | N.I. | Woods et al. (1993) |
i.p. | Sprague-Dawley rat | Male | 50 g | 316c | >1 × 108 | N.I. | Woods et al. (1993) |
i.t. | Sprague-Dawley rat | Male | 200–220 g | 1026b | 4 × 104 | 3 days | van Schaik et al. (2008) |
i.t. | Sprague-Dawley rat | Male | 200–220 g | 319a | <102 | 3 days | van Schaik et al. (2008) |
i.t. | Sprague-Dawley rat | Male | 200–220 g | VN-Rat | <102 | 3 days | van Schaik et al. (2008) |
i.t. | Sprague-Dawley rat | Male | 200–220 g | 1106a | 1.3 × 102 | 3 days | van Schaik et al. (2008) |
i.t. | Sprague-Dawley rat | Male | 200–220 g | 1106b | 2 × 102 | 3 days | van Schaik et al. (2008) |
i.t. | Sprague-Dawley rat | Male | 200–220 g | 1710a | 1.6 × 102 | 3 days | van Schaik et al. (2008) |
i.t. | Sprague-Dawley rat | Male | 200–220 g | 1710b | 2 × 102 | 3 days | van Schaik et al. (2008) |
i.t. | Sprague-Dawley rat | Male | 200–220 g | DD503 | 4.6 × 104 | 3 days | van Schaik et al. (2009) |
i.p., Intraperitoneal; s.c., subcutaneous; i.t., intratracheal; N.I., not indicated.