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. 2000 Oct;10(10):1568–1578. doi: 10.1101/gr.147000

Figure 4.

Figure 4

Pairwise interactions between unlinked QTL. (A) The BW-increasing interaction between the homozygous NON allele marked by D6Mit275 with the distal NZO-derived locus identified on chromosome 17 and marked by D17Mit240. Both alleles failed to show a main effect QTL because their effect is dependent on the presence of the other locus which, in a backcross, would only happen in ∼25% of the population. (B) The BW-increasing interaction between the “diabesity” QTL from NZO on chromosome 1 (here marked by D1Mit46) and the NZO-derived allele marked by D15Mit26. (C) The NON-derived effect at D2Mit182 elevating PG is only apparent when a NON-derived modifier at D15Mit26 is present in homozygous state. (D) The elevation in PG attributable to the interaction between the F1 maternal environment with the NZO-derived allele marked by D17Mit61. (E,F) Homozygosity for the NON-derived allele on chromosome 14 marked by D14Mit212 epistatically enhances the ability of the strong NZO-derived QTL on chromosome 12 marked by D12Mit231 to increase AI and BMI. (BW) body weight, (NON) nonobese nondiabetic, (PG) plasma glucose, (AI) adiposity index, (BMI) body mass index.