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. 2000 Oct;10(10):1568–1578. doi: 10.1101/gr.147000

Figure 5.

Figure 5

Three-way interactions with maternal environment. (A) The interaction between the F1 maternal environment, the NZO-derived allele marked by D1Mit76, and the homozygous NON-derived allele marked by D2Mit109. The interaction is only discernible at the very earliest time point (4 weeks) suggesting that it is particularly age dependent. (B) The increase in BW because of the interaction of the NZO-derived alleles marked by D1Mit123 and D17Mit61 with the F1 maternal environment. In the presence of the NON maternal environment, there is no significant effect of either locus. (C–G) The effects on PG of interactions between the F1 maternal environment and five separate pairs of NZO-derived alleles on chromosomes 1 × 12, 1 × 17, 1 × 15, 12 × 15, and 17 × 15. All five show a similar pattern of dramatically increased mean PG into the diabetic range only when all three diabetogenic parameters are present. (B) body weight; (NON) nonobese nondiabetic; (PG) plasma glucose.