Table 2.

Obese Maternal Environment Contributes to Diabetogenic Thresholds

Dam	n	BW (g) 4 wk	BW (g) 24 wk	PI (ng/mL) 16 wk	PG (mg/dL) 24 wk	BMI 24 wk	AI 24 wk	Leptin (ng/mL) 24 wk
F1 (obese)	89	23.4 ± 0.4	53.7 ± 0.7	10.3 ± 1.0	282 ± 14	.422 ± .004	13.4 ± .25	51.1 ± 2.0
NON (lean)	114	21.5 ± 0.3	48.8 ± 0.6	6.1 ± 0.7	208 ± 7	.393 ± .004	12.4 ± .20	41.8 ± 2.0

(BW) body weight; (PI) plasma insulin; (PG) plasma glucose; (BMI) body mass index; (AI) adiposity index. 

Values are mean ± SEM. Differences all significant at P ≤ 0.0003 except P = 0.0035 for AI and P = 0.0015 for leptin.