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(A) Chemical structure of γ-PNA. The oligomer contains regular nucleobases and the modified nucleobase, guanidinium G-clamp (X) replacing cytosine. (B) The G-clamp results in increased thermal stablility of matched duplexes due to formation of five hydrogen bonds with guanine. (C) Strand-invasion complex at binding of γ-PNA to a target sequence in duplex DNA. (D) Sequences of γ-PNA (PNA1) and DNA targets (only the displaced strand is shown) used in this study.
