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. 2010 Jul-Aug;1(1):44–61. doi: 10.4161/sgtp.1.1.12991

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Copyright © 2010 Landes Bioscience

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Rac GTPases and their regulators UNC-73/Trio and PIX-1 have unique and redundant roles in Q neuroblast protrusion and migration. (A) Unique roles of the Rac GTPases, CDC-42 and GEF regulators. MIG-2/RhoG, CDC-42 and PIX-1 all are required for Q neuroblast protrusion and migration and UNC-73/Trio is required for robust lamellipodial protrusion. CED-10 is required to limit Q neuroblast protrusion and migration. (B) Redundant roles of the Rac GTPases and GEF regulators. PIX-1 and UNC-73/Trio have redundant roles in Q neuroblast protrusion and migration. PIX-1 might act specifically in the CED-10/Rac pathway in parallel to MIG-2/RhoG.