Figure 1.

Early rapamycin treatment does not reduce bleomycin-induced acute lung injury in Sftpc ^+/+ or −/− mice. (a) Diagram of experimental protocol for prevention study to test affects of rapamycin on bleomycin-induced lung fibrosis. Sftpc ^+/+ and −/− mice were treated with daily rapamycin or vehicle 2 days prior to administration of intratracheal bleomycin or saline. (b) Changes in body weights, total BALF cells, BALF protein, and total lung collagen are shown fro Sftpc ^+/+ mice. (c) Changes in body weights, total BALF cells, BALF protein, and total lung collagen are shown for Sftpc ^−/− mice. (d) H&E stained representative lung histology is shown, all panels 40x magnification.