Figure 5.

Late rapamycin treatment alters bleomycin-induced changes in the lung mechanics of Sftpc ^−/− mice. Sftpc ^−/− mice were treated with daily rapamycin or vehicle beginning 8 days following administration of intratracheal bleomycin or saline. (a) Airway resistance was higher in mice receiving both bleomycin and rapamycin. (b) Compliance was decreased in mice receiving bleomycin compared to saline-treated mice and rapamycin-treated mice demonstrated significantly worse compliance than mice treated with vehicle.