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. Author manuscript; available in PMC: 2012 Mar 30.
Published in final edited form as: J Am Chem Soc. 2011 Mar 7;133(12):4558–4566. doi: 10.1021/ja110715f

Figure 7.

Figure 7

13C-detected water-filtered CP experiments on samples p2 (a) and p3 (b). The top row shows the 1H-13C CP signals in the absence of a T2 filter. A water-proton-selective T2 filter eliminates virtually all peptide signals (middle row). 7ms 1H-1H longitudinal mixing results in 1H polarization transfer from water into the fibrils (bottom). Gln18 and especially Gln19 signals remain suppressed in the water-filtered spectra (red arrows), whereas sites in the httNT helix are easily polarized (e.g., Lys6 in sample p3).