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Exhausted lymphopoiesis and persistent CD4+ T-cell count decline. Circulating CD34+, lymphoid HPCs, naive CD4+ T-cell, or CD8+ T-, B-, and NK-cell counts and percentages of CD38+ memory CD8+ T cells are shown for one donor at 2 different time points to highlight the association between declining CD4+ T-cell counts and exhaustion of lymphopoietic capacity despite low viral load before and after initiation of ART.
