Table 1.
P values of SNPs significantly associated with VWF antigen levels
| SNP | Log VWF level |
Location in the gene | Location in haplotype block | |
|---|---|---|---|---|
| Not ABO-adjusted | ABO-adjusted | |||
| rs2854871 | 6.6 × 10−6 .05 (.01) | 1.1 × 10−5 .04 (.01) | Intron 24 | Block 5 |
| rs11609815 | 9.4 × 10−8 .03 (.01) | 2.2 × 10−9 .03 (.01) | Intron 24 | Block 5 |
| rs11063995 | 8.9 × 10−8 .03 (.01) | 2.1 × 10−9 .03 (.01) | Intron 22 | Block 5 |
| rs216315 | 1.7 × 10−11 -.07 (.01) | 1.2 × 10−18 -.08 (.01) | Intron 22 | Block 5 |
| rs11612401 | 1.3 × 10−7 .03 (.01) | 3.2 × 10−9 .03 (.01) | Intron 22 | Block 5 |
| rs11610629 | 1 × 10−7 .03 (.01) | 2.8 × 10−9 .03 (.01) | Intron 22 | Block 5 |
| rs1800380 | 1.6 × 10−7 .03 (.01) | 4.4 × 10−9 .03 (.01) | Exon 22 | Block 5 |
| rs216318 | 1.7 × 10−11 -.07 (.01) | 1.3 × 10−18 -.08 (.01) | Intron 21 | Block 5 |
| rs11609728 | 1.2 × 10−7 .03 (.01) | 3.2 × 10−9 .03 (.01) | Intron 21 | Block 5 |
| rs11614912 | 4.9 × 10−7 .03 (.01) | 1.4 × 10−8 .03 (.01) | Intron 18 | Block 5 |
| rs1063857* | 3.9 × 10−19 .05 (.01) | 7.7 × 10−23 .05 (.01) | Exon 18 | Block 5 |
| rs216295 | 5.5 × 10−11 -.06 (.01) | 1 × 10−18 -.08 (.01) | Intron 17 | Block 5 |
| rs216298 | 5.7 × 10−11 -.06 (.01) | 7 × 10−19 -.08 (.01) | Intron 16 | Block 5 |
| rs216299 | 8.9 × 10−11 -.06 (.01) | 2.9 × 10−18 -.07 (.01) | Intron 16 | No |
| rs2239161 | 3.4 × 10−6 -.04 (.01) | 1.2 × 10−11 -.05 (.01) | Intron 15 | Block 6 |
| rs2239160 | 5.9 × 10−6 -.04 (.01) | 2.4 × 10−11 -.05 (.01) | Intron 15 | Block 6 |
| rs12304995 | 2.7 × 10−8 .03 (.01) | 1 × 10−9 .03 (.01) | Intron 15 | No |
| rs7139057 | 4.3 × 10−5 .03 (.01) | 9.3 × 10−6 .03 (.01) | Intron 13 | Block 7 |
| rs41388848 | .014-.04 (.02) | .00032-.05 (.01) | Intron 5 | Block 8 |
In each cell, the first row is the P value followed by the coefficient estimate (the increase of logVWF with one extra minor allele) and the corresponding SE.
*
Also identified in a GWAS by the CHARGE consortium.30