Table 1.
p53β and p53γ expression is associated with clinical markers
| All data | ||||
|---|---|---|---|---|
| Response variable | Predictor variable | β | P value | OR (95% CI) |
| p53β | p53γ | 1.01 | 0.008 | 2.75 (1.29 to 5.84) |
| p53γ | p53m | 1.47 | 0.002 | 4.33 (1.74 to 10.78) |
| p53β | 1.01 | 0.012 | 2.74 (1.24 to 6.04) | |
| p53m | p53γ | 1.74 | 0.002 | 5.70 (1.92 to 16.93) |
| p53β | -0.02 | 0.970 | 0.98 (0.28 to 3.43) | |
| Tumour grade 3 | 2.85 | <0.001 | 17.31 (4.02 to 74.45) | |
| ER | -2.74 | 0.019 | 0.06 (0.01 to 0.64) | |
| PR | 2.51 | 0.032 | 12.27 (1.25 to 120.74) | |
| Overall survival | p53m | -1.44 | 0.017 | 0.24 (0.07 to 0.78) |
| PR | 1.48 | 0.014 | 4.41 (1.34 to 14.45) | |
| Tumour size | -1.22 | 0.036 | 0.29 (0.09 to 0.93) | |
| p53γ | -0.18 | 0.783 | 0.83 (0.22 to 3.10) | |
| p53β | 1.15 | 0.082 | 3.17 (0.87 to 11.60) | |
| Cancer recurrence | p53m | 1.25 | 0.013 | 0.29 (0.11 to 0.76) |
| PR | -1.26 | 0.009 | 3.52 (1.37 to 9.04) | |
| p53γ | -0.28 | 0.636 | 1.33 (0.41 to 4.30) | |
| p53β | -0.74 | 0.198 | 2.10 (0.68 to 6.47) | |
Variables were analysed using binary logistic regression analysis utilising the backwards stepwise elimination method. Lymph node status, tumour grade, p53 mutation status (p53m), p53β, p53γ, human epidermal growth factor receptor 2 (HER2 or ErbB2), oestrogen receptor (ER) and progesterone receptor (PR) expression were included in the analyses as predictor variables. All independent significant associations between the predictor and response variables were identified (results of run 1). Dependent associations (results of runs 2, 3, 4, and so on) are omitted. Only results related to p53 and clinical outcome are presented. Results related to ER/PR, tumour grade and lymph node status are presented in Table S4 in Additional file 1. The β coefficients and the odds ratios (OR) with 95% confidence intervals (95% CI) are indicated.