Table 3.
Cox regression analyses: p53 mutation status in p53 mutant breast cancer patients expressing p53γ is not associated with death and cancer recurrence
| Death | Recurrence | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ID | Run | Predictor | β | P | RR (95% CI) | Run | Predictor | β | P | RR (95% CI) |
| a | 1 | Tumour grade 3 | 2.12 | 0.005 | 8.33 (1.90 to 36.47) | 1 | PR | -0.99 | 0.021 | 0.37 (0.16 to 0.86) |
| b | 2 | PR | -1.36 | 0.011 | 0.26 (0.09 to 0.74) | 1 | p53m | 1.06 | 0.012 | 2.87 (1.27 to 6.51) |
| c | 2 | p53m | 1.1 | 0.026 | 3.00 (1.14 to 7.85) | 2 | Tumour grade 3 | 1.51 | 0.003 | 4.52 (1.60 to 12.11) |
| d | 3 | ER | -1.54 | 0.002 | 0.21 (0.08 to 0.55) | 3 | HER2 | 1.16 | 0.012 | 3.18 (1.29 to 7.83) |
| e | 4 | HER2 | 1.21 | 0.026 | 3.35 (1.16 to 9.65) | 4 | ER | -1.05 | 0.012 | 0.35 (0.16 to 0.79) |
| f | 5b | Lymph nodes | 1.19 | 0.037 | 3.30 (1.08 to 10.13) | 5b | Lymph nodes | 0.93 | 0.039 | 2.53 (1.05 to 6.09) |
| g | 6b | p53β | -0.38 | 0.491 | 0.69 (0.24 to 2.00) | 6b | p53β | -0.17 | 0.699 | 0.84 (0.35 to 2.03) |
| h | 6b | p53γ | 0.48 | 0.337 | 1.61 (0.61 to 4.29) | 6b | p53γ | 0.19 | 0.652 | 1.21 (0.52 to 2.81) |
| i | 5b | p53m&p53β+ | 0.07 | 0.451 | 1.47 (0.54 to 3.99) | 5b | p53m&p53β+ | 0.97 | 0.053 | 2.65 (0.99 to 7.10) |
| j | 5b | p53m&p53γ+ | 0.31 | 0.626 | 1.36 (0.39 to 4.75) | 5b | p53m&p53γ+ | 0.49 | 0.333 | 1.63 (0.61 to 4.36) |
| k | 2 | p53m&p53β+ p53γ- | 2.87 | 0.017 | 17.56 (1.66 to 186.15) | 4 | p53m&p53β+&p53γ- | 1.71 | 0.021 | 5.51 (1.29 to 23.57) |
| l | 5b | p53m&p53γ+&p53β- | 0.78 | 0.298 | 2.19 (0.50 to 9.59) | 5b | p53m&p53γ+&p53β- | 0.31 | 0.679 | 1.36 (0.32 to 5.78) |
aVariables were analysed using Cox proportional hazards regression model utilising the backwards stepwise elimination method. Lymph node status, tumour grade, p53 mutation status (p53m), p53β, p53γ, human epidermal growth factor receptor 2 (HER2 or ErbB2), oestrogen receptor (ER) and progesterone receptor (PR) expression were included in analyses as predictor variables. The run number refers to the run in which the predictor variable was deemed to be statistically significantly associated with the response variable (death or recurrence) and thereafter was excluded from further runs. Rows a-f refer to the statistically significant results in the first iteration of analyses without interaction variables. Of the variables that were not associated with the response variables, p53β and p53γ are included in the table (rows g and h), but others are omitted for clarity and brevity. Rows i-l refer to results of Cox regression analyses for the interaction predictor variables shown in the presence of all the above predictor variables (data not shown for clarity and brevity). The β coefficient and the risk ratio (RR) with 95% confidence intervals (95% CI) are indicated; bFinal run in a given set of analyses.