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. 2011 Feb 2;13(1):R15. doi: 10.1186/bcr2824

Figure 1.

Figure 1

Gene amplification distribution on chromosome 17q12-q21 in Human epidermal growth factor receptor 2 (HER2)-positive breast cancer specimens on the basis of the overview of chromosome 17 with the National Center for Biotechnology Information's Sequence Viewer version 2.9 database [55]. The frequency of amplification (percentage of positive breast cancer specimens on the y-axis) for a gene decreases with the increase of its distance from HER2. MED1, mediator complex subunit 1 gene; STARD3, steroidogenic acute regulatory-related lipid transfer (START) domain containing 3 gene; HER2, human epidermal growth factor receptor 2 gene; GRB7, growth factor receptor-bound protein 7 gene; THRA, thyroid hormone receptor α gene; RARA, retinoic acid receptor α gene; TOP2A, topoisomerase IIα gene; IGFBP4, insulin-like growth factor-binding protein 4 gene; CCR7, C-C chemokine receptor type 7 gene; KRT20, cytokeratin 20 gene; KRT19, cytokeratin 19 gene; GAS, gastrin gene.