Table 2.
Tamoxifen Insensitive genes Repressed by the Apo-ER -> Apo-RARα Axis
| Gene | ATRA effect |
RAR a binding <10 kb | Fold change siER | Fold change siRARα1 | Gene | ATRA effect | RAR a binding <10 kb | Fold change siER | Fold change siRARα1 |
|---|---|---|---|---|---|---|---|---|---|
| IFI44L | ↓ | + | 1.69 | 2.22 | UBL3 | - | ++ | 1.61 | 1.58 |
| IFI44 | ↓ | - | 2.09 | 2.28 | SLC7A11 | - | ++ | 1.71 | 2.03 |
| CCPG1 | ↓ | - | 1.67 | 1.56 | KIAA0652 | - | ++ | 1.57 | 1.63 |
| SLC25A36 | ↓ | - | 1.66 | 1.73 | PHLDB1 | - | ++ | 1.64 | 1.55 |
| SETD5 | ↓ | ++ | 1.52 | 2.11 | CCNT2 | - | - | 1.53 | 1.63 |
| MALL | ↓ | - | 1.67 | 1.81 | STX3 | - | - | 1.52 | 1.59 |
| LYPD1 | ↓ | - | 1.66 | 1.59 | CLN8 | - | - | 1.71 | 1.72 |
| FAM186A | ↓ | - | 1.64 | 1.75 | UBXN10 | - | - | 1.73 | 1.64 |
| GPR158 | ↓ | - | 1.81 | 1.54 | PVR | - | - | 1.63 | 2.39 |
| CDKN1A | ↓ | - | 1.70 | 1.51 | TNFRSF10A | - | - | 1.54 | 1.62 |
| CEACAM6 | ↑ | + | 2.35 | 1.63 | FLJ31958 | - | - | 1.71 | 1.52 |
| LGALS3BP | ↑ | - | 1.98 | 1.92 | C18orf25 | - | - | 1.50 | 1.61 |
| CTSS | ↑ | - | 1.50 | 1.86 | TAPBP | - | - | 1.62 | 1.51 |
| SELL | ↑ | - | 1.75 | 1.71 | ADAM17 | - | - | 1.58 | 1.63 |
| SHROOM1 | ↑ | - | 1.68 | 1.59 | HCP5 | - | - | 1.59 | 2.52 |
| CP | ↑ | ++ | 1.71 | 1.75 | DISC1 | - | - | 1.80 | 1.74 |
| ABHD2 | ↑ | ++ | 1.56 | 1.57 | SP100 | - | - | 1.77 | 1.61 |
| ABLIM1 | ↑ | ++ | 1.56 | 1.55 | AASS | - | - | 1.53 | 2.17 |
| ALOX5 | ↑ | - | 1.72 | 2.09 | HLA-G | - | - | 1.50 | 2.33 |
| HLA-C | ↑ | - | 1.51 | 2.51 | HLA-B | - | - | 1.61 | 2.08 |
| MAP1B | ↑ | - | 2.12 | 1.51 | RSAD2 | - | - | 1.84 | 3.19 |
| ARHGAP1 | ↑ | - | 1.58 | 1.55 | SGSM3 | - | - | 1.72 | 1.50 |
| SP110 | ↑ | - | 1.58 | 1.63 | HLA-J | - | - | 1.52 | 2.04 |
| RTP4 | ↑ | - | 1.60 | 1.81 | SESN1 | - | - | 1.53 | 1.60 |
| MUC20 | ↑ | - | 1.75 | 1.91 | ANO10 | - | - | 1.51 | 1.64 |
| RNF38 | - | + | 1.80 | 1.69 | SAMD9 | - | - | 1.68 | 1.56 |
| C9orf80 | - | + | 1.64 | 1.53 | FLJ13197 | - | - | 1.68 | 1.57 |
| CEACAM5 | - | - | 2.35 | 1.70 | PGLS | - | - | 1.54 | 1.81 |
| CNOT4 | - | - | 1.79 | 1.92 | LMO3 | - | - | 1.61 | 1.58 |
| PLXNA2 | - | - | 1.65 | 1.86 | DNAJC21 | - | - | 1.68 | 1.61 |
| TTC9 | - | - | 1.76 | 1.51 | SETD2 | - | - | 1.52 | 2.11 |
| EIF5A2 | - | - | 1.90 | 1.67 | ZNF24 | - | - | 2.10 | 1.68 |
| FLCN | - | ++ | 1.51 | 1.53 | TTLL11 | - | - | 1.72 | 1.51 |
| BAZ2A | - | ++ | 1.53 | 1.58 | ZNF544 | - | - | 1.58 | 1.71 |
a RAR binding site identified within 10 kb of the transcription start site (Hua et al., 2009).
++ RAR binding site detected under high stringency (Hua et al., 2009).
+ RAR binding site detected under low stringency (Hua et al., 2009).
↑ Up-regulated by ATRA (1 μM, 24 h) ≥2-fold.
↓ Down-regulated by ATRA (1 μM, 24 h) ≤50%.
Abbreviations: ER, estrogen receptor; RAR, retinoic acid receptor; ATRA, all trans-retinoic acid; si, small interfering RNA.