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. Author manuscript; available in PMC: 2011 Jun 7.
Published in final edited form as: J Med Chem. 2010 May 13;53(9):3772–3781. doi: 10.1021/jm100235h

Figure 5.

Figure 5

Bisazole molecular models. A: 1 – s-cis bithiazole conformation (active conformation; see s-cis-locked bithiazole 2 in Figure 1). B: 11d – Nγ substituted pyrazole ring nearly orthogonal to the thiazole ring. C: 14g – Nβ substituted s-cis pyrazolylthiazole → places Nβ benzyl moiety in the same region of space as the aniline moiety in 1. D: 14g – Nβ substituted s-trans pyrazolylthiazole → places the C5 amide moiety in the same region of space as the aniline moiety in 1.