Scheme 2.
Synthesis of Nβ-substituted pyrazolylthiazole.
Reagents: (a) NH2NH2·H2O, EtOH (b) R2Br, K2CO3, Acetone, 60 °C (c) R3R3′NH, AlMe3, DCM, MW, 100 °C (d) NH2(CH2)2OH, EtOH, MW 180 °C (e) NaOH, THF/H2O.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.