Table 1.

Nγ-Substituted pyrazolylthiazole analogs.

R¹ = C(CH₃)₃, C₆H₅

R² = CH₂CH=CH₂, C₆H₄(4-Br), CH₂C₆H₅, (CH₂)₂OH

X = OEt, NHC₆H₄(4-OMe), NHCH₂C₆H₅, NH(CH₂)₂OH, N(CH₂CH₂)₂O, OH

Compd	R1	R2	X
9a	C(CH3)3	CH2CH=CH2	OEt
9b	C(CH3)3	C6H4(4-Br)	OEt
9c	C(CH3)3	CH2C6H5	OEt
9d	C(CH3)3	CH2CH2OH	OEt
9e	C6H5	CH2CH=CH2	OEt
9f	C6H5	C6H4(4-Br)	OEt
9g	C6H5	CH2C6H5	OEt
9h	C6H5	CH2CH2OH	OEt
11a	C(CH3)3	CH2CH=CH2	NHC6H4(4-OMe)
11b	C(CH3)3	CH2CH=CH2	NHCH2C6H5
11c	C(CH3)3	CH2CH=CH2	N(CH2CH2)2O
11d	C(CH3)3	C6H4(4-Br)	NHC6H4(4-OMe)
11e	C(CH3)3	C6H4(4-Br)	NHCH2C6H5
11f	C(CH3)3	C6H4(4-Br)	N(CH2CH2)2O
11g	C(CH3)3	CH2C6H5	NHC6H4(4-OMe)
11h	C(CH3)3	CH2C6H5	NHCH2C6H5
11i	C(CH3)3	CH2C6H5	N(CH2CH2)2O
11j	C(CH3)3	CH2CH2OH	NHC6H4(4-OMe)
11k	C(CH3)3	CH2CH2OH	NHCH2C6H5
11l	C(CH3)3	CH2CH2OH	N(CH2CH2)2O
11m	C6H5	CH2CH=CH2	NH(CH2)OH
11n	C6H5	C6H4(4-Br)	NH(CH2)OH
11o	C6H5	CH2C6H5	NH(CH2)OH
11p	C6H5	CH2CH2OH	NH(CH2)OH
11q	C6H5	CH2CH=CH2	NHC6H4(4-OMe)
11r	C6H5	C6H4(4-Br)	NHC6H4(4-OMe)
11s	C6H5	CH2C6H5	NHC6H4(4-OMe)
11t	C6H5	CH2CH2OH	NHC6H4(4-OMe)
11u	C6H5	CH2CH=CH2	N(CH2CH2)2O
11v	C6H5	C6H4(4-Br)	N(CH2CH2)2O
11w	C6H5	CH2C6H5	N(CH2CH2)2O
11x	C6H5	CH2CH2OH	N(CH2CH2)2O
12a	C(CH3)3	CH2CH=CH2	OH
12b	C(CH3)3	C6H4(4-Br)	OH
12c	C(CH3)3	CH2C6H5	OH
12d	C6H5	CH2CH=CH2	OH
12e	C6H5	C6H4(4-Br)	OH
12f	C6H5	CH2C6H5	OH
12g	C6H5	CH2CH2OH	OH