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. Author manuscript; available in PMC: 2011 Jun 7.
Published in final edited form as: J Med Chem. 2010 May 13;53(9):3772–3781. doi: 10.1021/jm100235h

Table 3.

Pyrazolylthiazole DF508-CFTR corrector activity.

corrector
structure		 corrector
number		 EC50 (μM)a Vmax (μM/s)b
graphic file with name nihms-295551-t0012.jpg 10b 8.5 2.6
graphic file with name nihms-295551-t0013.jpg 11d 3.4 2.5
graphic file with name nihms-295551-t0014.jpg 14a 0.93 0.5
graphic file with name nihms-295551-t0015.jpg 14b 3.0 1.4
graphic file with name nihms-295551-t0016.jpg 14e 0.75 1.0
graphic file with name nihms-295551-t0017.jpg 14g 1.0 6.1
graphic file with name nihms-295551-t0018.jpg 14h 1.0 7.26
graphic file with name nihms-295551-t0019.jpg 14j 3.0 2.4
a

Concentration where the increased I− influx is 50% of Vmax.

b

Vmax is maximum increase in I− influx due to compound effect.