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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Future Oncol. 2011 Feb;7(2):253–261. doi: 10.2217/fon.10.191

Figure 1. DNA repair genes associated with hereditary breast cancer and linked to Fanconi anemia.

Figure 1

Genetic susceptibility to breast cancer is attributed to germline mutations in either BRCA1 or BRCA2 as well as other genes, notably some genes that encode for BRCA1- and BRCA2-interacting proteins, FANCJ and PALB2. The percentage of contribution of the non-BRCA genes is unclear and not indicated. Inheriting bi-allelic mutations in some breast cancer genes, which are underlined, results in Fanconi anemia associated with complementation groups BRCA2/FANCD1, PALB2/FANCN and BACH1/FANCJ/BRIP1.