Table 5. Validation of microarray data using RT-PCR.
| Gene | Fold changea | Change in gene vs. change in referenceb |
|---|---|---|
| IIGP | 296 | 368 |
| TGTP | 203 | 252 |
| IRG-47 | 69 | 86 |
| IGTP | 43 | 54 |
| GTPI | 28 | 35 |
| LRG-47 | 15 | 18 |
Fold change was calculated using the difference between Ct values between IFN-γ treated vs. untreated astrocytes for each of the different p47 GTPases and also using actin as a reference gene and change in gene vs. change in reference calculated using the Pfaffl method (Pfaffl, 2001).
Fold change=Difference in Ct between IFN-γ treated vs. untreated astrocytes.
Change in gene as determined using actin as a reference using the Pfaffl method.