Figure 1.

Features of HEAT-repeat proteins. (a) Typical structure of a repeat. Sidechain atoms for more highly conserved positions are shown. The structure and sequence corresponds to repeat-10 of importin-β (1QGKA). (b) Schematic representation of domain architectures. HEAT repeats are colored red in proportion to their profile scores, using lighter shades for less conserved repeats. Protein names are colored by families. “Explosions” indicate compositionally biased regions and are shaded red for acidic, blue for basic, and green for uncharged polar biases. Other domains are as indicated.