Table 2.
Functional grouping of differentially expressed genes
| Functional group/gene | Fold difference | P | Significance |
|---|---|---|---|
| Interferon response | |||
| PYHIN1 (IFIX), (growth interferon-inducible protein X) | 2.8 | .000052 | Interferon-inducible HIN-200 gene family member17 |
| MNDA (myeloid nuclear differentiation antigen) | 2.2 | .0092 | HIN-200 gene family member17,19 |
| OAS1 (2′, 5′ oligoadenylate cyclase) | 2.1 | .000052 | IFN-inducible gene which activates RNaseL |
| B-cell anergy | |||
| LGALS1 (galectin-1) | 3.6 | .00038 | Negatively regulates B-cell proliferation upon BCR ligation14; up-regulated in anergic murine B cells12 |
| CD200R1 (CD200 receptor 1) | 2.4 | .0034 | Inhibitory receptor highly expressed on memory B cells and plasmablasts; definitive role in B cell activation not established11 |
| LAX1 (lymphocyte transmembrane adapter 1) | 2.1 | .032 | Dampens B-cell response to BCR engagement16 |
| B-cell apoptosis | |||
| LGALS1 | 3.6 | .00038 | Expressed in IgM+ memory cells, reported to enhance apoptosis via inhibition of Akt phosphorylation and up-regulation of Bim13 |
| PYHIN1 | 2.8 | .000052 | As an HIN-200 gene family member, contains an N-terminal PAAD/DAPIN/Pyrin domain that mediates binding with proteins involved in apoptotic NF-κB and caspase signaling17 |
| DAPK2 (death-associated protein kinase 2) | 2.4 | .043 | Calcium/calmodulin-dependent protein kinase, which induces apoptosis15 |
| MNDA | 2.2 | .0092 | As an HIN-200 gene family member, contains an N-terminal PAAD/DAPIN/Pyrin domain that mediates binding with proteins involved in apoptotic NF-κB and caspase signaling17 |
| B-cell survival | |||
| TCL1A (T-cell lymphoma antigen 1A) | 0.34 | .000075 | Reported to enhance B-cell survival by induction of Mcl-113 |
| B-cell lymphomagenesis | |||
| SOX5 (SRY-box 5) | 3.6 | .00062 | Reported to be up-regulated in splenic follicular lymphoma20 |
| ITGAX, (CD11C), (integrin, α X) | 2.9 | .00066 | High expression associated with splenic marginal zone lymphoma21 |
| MNDA | 2.2 | .0092 | Expressed in marginal zone B cells, up-regulated in marginal zone lymphoma22 |
| BACH2 | 0.46 | .022 | Down-regulated in Waldenström macroglobulinemia10 |
| FOXP1 | 0.44 | .00072 | Up-regulation of FOXP1 in mucosa-associated lymphoid tissue lymphoma may be associated with neoplastic transformation23 |
| TCL1A (T-cell lymphoma 1A) | 0.34 | .00075 | Up-regulated in splenic marginal zone lymphoma18 |
| SELL (L-selectin) | 0.34 | .00031 | Up-regulated in splenic marginal zone lymphoma18 |
| IL-4R (IL-4 receptor) | 0.31 | .00017 | Down-regulated in mantle cell lymphoma9 and Waldenström macroglobulinemia10 |
| LMO2 (LIM domain only 2) | 0.31 | .0010 | Up-regulation corresponds to increased survival in diffuse large B-cell lymphoma24 |
IFN indicates interferon; PAAD/DAPIN, Pyrin, AIM (Absent in Melanoma), ASC (Apoptosis-associated-speck-like protein containing a caspase recruitment domain [CARD]) and death-domain (DD)-like Domain in Apoptosis and Interferon response; and NFκB, nuclear factor-κB.
*
Bonferroni corrected.