Figure 5.

The effect of Arc/Arg3.1 knockdown on auditory fear memory reconsolidation is temporally graded. a, Schematic of the behavioral protocol. b, Postshock freezing scores in Arc/Arg3.1 ODN (n = 5) and scrambled ODN (n = 4) groups immediately after the conditioning trials. c, Freezing scores in each group during the memory reactivation trial. d, PR-LTM assessed 18 h after infusions for both antisense and scrambled groups. e, Histological verification of cannula placements for rats infused with Arc/Arg3.1 antisense (white circles) or scrambled (black circles) ODNs. Panels adapted from Paxinos and Watson (1998).