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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Lab Invest. 2010 Oct 4;91(1):4–11. doi: 10.1038/labinvest.2010.173

Figure 1. Regulation of complement activation.

Figure 1

Three complement activation pathways - the classical, mannose binding lectin and alternative pathways - can form C3 convertases. Cleavage of C3 then enables formation of C5 convertases, which ultimately generate the membrane attack complex. The complement regulatory proteins (in boxes) block this cascade at several steps.