Table 3.
Predicted Six-Year Change* in Other Biomarkers at Selected Ages, by Sex
| Males | Females | |||||
|---|---|---|---|---|---|---|
| Age at baseline (2000) | 55 | 65 | 75 | 55 | 65 | 75 |
| Age at followup (2006) | 61 | 71 | 81 | 61 | 71 | 81 |
| Creatinine clearance (ml/min) | NS | −5.27 | −6.47 † | NS | −5.74 | −8.28 † |
| % Change‡ | −8% | −10% | −9% | −13% | ||
| Albumin (g/dL) | −0.19 | −0.18 | −0.17 | −0.13 | −0.15 | −0.17 |
| % Change‡ | −4% | −4% | −4% | −3% | −3% | −4% |
| Leukocyte count (103/μL) | NS | NS | 0.39 | NS | NS | NS |
| % Change‡ | 7% | |||||
| Interleukin-6 (pg/mL) | NS | 0.69 | 1.33 † | NS | NS | 1.02 |
| % Change‡ | 21% | 41% | 31% | |||
| Cortisol (μg/g creatinine) | NS | NS | NS | NS | −5.98 | NS |
| % Change‡ | −24% | |||||
| Epinephrine (μg/g creatinine) | NS | 0.44 | NS | NS | NS | NS |
| % Change‡ | 12% | |||||
| Norepinephrine (μg/g creatinine) | 4.10 | 5.09 | 6.08 | 4.63 | 6.39 | 8.14 |
| % Change‡ | 19% | 24% | 28% | 22% | 30% | 38% |
| Dopamine (μg/g creatinine) | 19.96 | 14.09 | NS | NS | 16.52 | NS |
| % Change‡ | 11% | 8% | 9% | |||
*
Refer to notes on Table 2. The model for creatinine clearance among men also includes a quadratic term for age.
†
Change in biomarker varied significantly (p<0.01) by age at baseline. For the model of creatinine clearance among men, we performed a joint test for age and age2.
‡
Refer to notes on Table 2.
NS = Predicted change did not differ significantly from zero (at the p<0.01 level based on an F-test).